What Silences the Spindle Checkpoint? A Single Particle Study
نویسندگان
چکیده
منابع مشابه
The signaling network that silences the spindle assembly checkpoint upon the establishment of chromosome bipolar attachment.
Improper kinetochore attachments activate the spindle assembly checkpoint (SAC) to prevent anaphase onset, but it is poorly understood how this checkpoint is silenced to allow anaphase onset. Chromosome bipolar attachment applies tension on sister kinetochores, and the lack of tension delays anaphase onset. In budding yeast, the delay induced by tension defects depends on the intact SAC as well...
متن کاملThe spindle assembly checkpoint
Italian in 1954, so Imanishi turned to the exploration of the unexplored wide range of Karakorum Himalayas, traversing the three major glaciers in 1955. Then, in 1958, Imanishi and Itani went to Africa for the first time. In the same year, Nishibori led the all-Japanese team which succeeded in the first over-wintering stay in Antarctica. Kuwabara led the Himalayan expedition of AACK to the firs...
متن کاملThe spindle checkpoint.
Every mitosis, replicated chromosomes must be accurately segregated into each daughter cell. Pairs of sister chromatids attach to the bipolar mitotic spindle during prometaphase, they are aligned at metaphase, then sisters separate and are pulled to opposite poles during anaphase. Failure to attach correctly to the spindle before anaphase onset results in unequal segregation of chromosomes, whi...
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One of the most awe-inspiring demonstrations in biology is a timelapse video of mitosis viewed with high magnification phase contrast or Nomarski DIC microscopy. From initial chaotic movement comes the orderly alignment of chromosomes at the metaphase plate followed by a flawlessly synchronous splitting of the chromosomes and their gliding separation to the two mitotic poles. Enforcing the timi...
متن کاملThe Spindle Assembly Checkpoint
During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.2304